منابع مشابه
Cell Protrusions
Introduction How do cells move? There is no shortage of theories, but a definitive answer is still elusive. Here we will present some models for cell motions along with proposals for experiments to address the theories. We will restrict ourselves to the problem of cell protrusion, although the models apply to other motility phenomena as well. Different protrusion phenomena extend at different c...
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Systemic metastasis is the dissemination of cancer cells from the primary tumor to distant organs and is the primary cause of death in cancer patients. How do cancer cells leave the primary tumor mass? The ability of the tumor cells to form different types of actin-rich protrusions including invasive protrusions (invadopodia) and locomotory protrusions (lamellipodia [2D] or pseudopodia [3D]), f...
متن کاملCell protrusions and tethers: a unified approach.
Low pulling forces applied locally to cell surface membranes produce viscoelastic cell surface protrusions. As the force increases, the membrane can locally separate from the cytoskeleton and a tether forms. Tethers can grow to great lengths exceeding the cell diameter. The protrusion-to-tether transition is known as the crossover. Here we propose a unified approach to protrusions and tethers p...
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Microtentacles are mostly microtubule-based cell protrusions that are formed by detached tumor cells. Here, we report that the formation of tumor cell microtentacles depends on the presence and dynamics of guanine nucleotide-binding proteins of the septin family, which are part of the cytoskeleton. In matrix-attached breast, lung, prostate and pancreas cancer cells, septins are associated with ...
متن کاملCOMMENTARY Polarization of pseudopodial activities: cytoskeletal mechanisms
Polarization of pseudopodial activities can be defined as a more or less stable division of the cell surface into pseudopodium-extending active zones and non-active zones. Polarization is the basis of numerous phenomena involved in morphogenesis and cell motility; the spectrum of these phenomena ranges from the crawling of amoebae to axon elongation. Direction of polarization is often determine...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m501754200